Work

Immune system versus tumor: shifting the balance in favor of DCs and effective immunity

Year: 2004

Type: article

Abstract: Despite the initial excitement over cancer vaccines, the clinical effectiveness of immunotherapy has been disappointing. The suppressive milieu present within established tumors inhibits effective immune responses, although new strategies are emerging to manipulate the local tumor microenvironment and shift the balance back to a proinflammatory environment, promote DC activation, and enhance tumor immunity.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci200421148

Authors: Howard L. Kaufman, Mary L. Disis

Institutions: Columbia University Irving Medical Center, Columbia University

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Doris Duke Charitable Foundation, National Institutes of Health, U.S. Public Health Service, National Cancer Institute