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The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc

Year: 2014
Type: article
Abstract: Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space. The cellular metabolism (synthesis and catabolism) of hyaluronan is dynamic. UDP-GlcNAc is also the substrate for O-GlcNAc transferase, which is central to the control of many cytosolic pathways. This Perspective outlines recent data for regulation of hyaluronan synthesis and catabolism that support a model that hyaluronan metabolism can be a rheostat for controlling an acceptable normal range of cytosolic UDP-GlcNAc concentrations in order to maintain normal cell functions.
DOI: 10.1016/j.matbio.2014.01.014
Authors: Vincent C. Hascall, Aimin Wang, Markku Tammi, Sanna Oikari, Raija Tammi, Alberto Passi, Davide Vigetti, Richard W. Hanson, Gerald W. Hart
Institutions: Cleveland Clinic, University of Eastern Finland, University of Insubria, Case Western Reserve University, Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Cell Biology
Open Access status: hybrid
Estimated APC paid: $4,280
OpenAlex ID: W2059047617
FWCI: 6.478
Cites: 20
Cited by: 102
Related to: 10