Work

Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases

Year: 2004

Type: article

Abstract: A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200454045

Authors: Manfred Mutter, Arunan Chandravarkar, Christine Boyat, John Lopez, Sonia Dos Santos, Bhubaneswar Mandal, Richard Mimna, Karine Murat, Luc Patiny, Lydiane Saucède, Gabriele Tuchscherer

Institution: École Polytechnique Fédérale de Lausanne

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2059236390

FWCI: 7.492

Cites: 78

Cited by: 164

Related to: 10