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DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability

Year: 2013
Type: article
Abstract: Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs leads to reduced FoxP3 expression in Treg cells in vivo. In vitro culture of purified DGCR8-deficient Treg leads to a loss of FoxP3 expression. We conclude that canonical miRNAs are essential to maintain stable FoxP3 expression and Treg function. Thus, signals interfering with miRNA homeostasis might contribute to autoimmune diseases.
Source: PLoS ONE
DOI: 10.1371/journal.pone.0066282
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,382
Funders: National Science Foundation, Novartis Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1239756754, G2475776325, G3751938457, G4078016468, Autoimmunity Center of Excellence, G596423134, The role of microRNAs in regulatory T cell biology in health and disease, Analysis of small RNA function in regulatory T cell biology, G9000086411, G9000231504
OpenAlex ID: W2059286116
FWCI: 2.024
Cites: 49
Cited by: 23
Related to: 10