33: Similar Graft-Versus-Leukemia Effect Using Matched Unrelated Donors, Compared to HLA-Identical Siblings for Hematopoietic Stem Cell Transplantation
Year: 2008
Type: article
Study design: Observational Study
Abstract: With better matching due to genomic tissue typing and improved immunosuppression, hematopoietic stem cell transplant (HSCT) using HLA-matched unrelated donors (URD) have similar outcome as using HLA-identical sibling donors (sib). Do some leukemia patients benefit from an URD transplant, because of a stronger graft-versus-leukemia (GVL) effect? We analyzed the outcome in 941 URD (8/8 HLA-allele matched) transplants, compared to 3158 sib HSCT for acute leukemia (AML and ALL) and chronic myeloid leukemia (CML) receiving myeloablative conditioning between 1995–2004 and reported to the CIBMTR.
Authors: O.T.H. Ringden, S. Pavletic, C. Anasetti, J.A. Barrett, T. Wang, J.H. Antin, P. Di Bartolomeo, B.J. Bolwell, C. Bredeson, M.S. Cairo, R.P. Gale, S. Giralt, T. Hahn, G.A. Hale, J. Halter, M. Jagasia, M.R. Litzow, F. Locatelli, P.L. McCarthy, M.J. Cowan, E.W. Petersdorf, J.A. Russel, G.J. Schiller, H. Schouten, M.S. Tallman, L.F. Verdonck, J.M. Wiley, J.R. Wingard, M.M. Horowitz, M. Arora
Institutions: Karolinska University Hospital, National Institutes of Health, Moffitt Cancer Center, Medical College of Wisconsin, Brigham and Women's Hospital, Azienda USL di Pescara, Cleveland Clinic, Manitoba Health, Columbia University Irving Medical Center, The University of Texas MD Anderson Cancer Center, Roswell Park Comprehensive Cancer Center, St. Jude Children's Research Hospital, University Hospital of Basel, Vanderbilt University Medical Center, Mayo Clinic, Policlinico San Matteo Fondazione, Fred Hutch Cancer Center, University of California, Los Angeles, Maastricht University Medical Centre, Northwestern University, University Medical Center Utrecht, Sinai Hospital, University of Florida Health, University of Florida, University of Minnesota
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2059289069