Work

Magnetic Nanoparticle-Based Approaches to Locally Target Therapy and Enhance Tissue Regeneration In Vivo

Year: 2012

Type: review

Abstract: Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto-mechanical cell stimulation, cell seeding and cell patterning.

Source: Nanomedicine

DOI: 10.2217/nnm.12.109

Authors: Richard Sensenig, Yulia Sapir, Cristin MacDonald, Smadar Cohen, Boris Polyak

Institutions: Drexel University, Ben-Gurion University of the Negev

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute