Year: 1999
Type: review
Abstract: It is now generally accepted that massive neuronal death due to oxidative stress is a common characteristic of brains in neurodegenerative diseases. Recently, numerous apoptosis-regulating factors and multiple pathways have been identified, and apoptotic cell death has been implicated in neuronal loss in Alzheimer's disease. Although glial cells are more resistant to oxidative stress than neurons, extensive oxidative stress seems to cause apoptotic cell death in glial cells. In fact, signs of apoptosis are observed in both neurons and glial cells in the brains of patients with Alzheimer's disease. This review summarizes current findings regarding apoptotic processes and discusses the possible involvement of apoptosis-regulating factors in the pathology of Alzheimer's disease.
DOI: 10.1254/jjp.79.1
Authors: Kitamura Yoshihisa, Taniguchi Takashi, Shimohama Shun
Institutions: Kyoto Pharmaceutical University, Kyoto University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2059304461