High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 + and CD4 + T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
Year: 2007
Type: article
Study design: Observational Study
Abstract: We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
Source: Journal of Virology
DOI: 10.1128/jvi.02474-07
Authors: Victoria Kasprowicz, Julian Schulze zur Wiesch, Thomas Kuntzen, Brian E. Nolan, Steven Longworth, Andrew Berical, Jenna Blum, Cory McMahon, Laura L. Reyor, Nahel Elias, William W. Kwok, Barbara G. McGovern, Gordon Freeman, Raymond T. Chung, Paul Klenerman, Lia Lewis-Ximenez, Bruce D. Walker, Todd M. Allen, Arthur Y. Kim, Georg M. Lauer
Institutions: Harvard University, Massachusetts General Hospital, Howard Hughes Medical Institute, Universität Hamburg, Benaroya Research Institute, Tufts University, Lemuel Shattuck Hospital, Dana-Farber Cancer Institute, University of Oxford, Medawar Building for Pathogen Research, Instituto Oswaldo Cruz
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2059384462