Work

Soma‐germline interactions that influence germline proliferation in Caenorhabditis elegans

Year: 2010

Type: review

Abstract: Caenorhabditis elegans boasts a short lifecycle and high fecundity, two features that make it an attractive and powerful genetic model organism. Several recent studies indicate that germline proliferation, a prerequisite to optimal fecundity, is tightly controlled over the course of development. Cell proliferation control includes regulation of competence to proliferate, a poorly understood aspect of cell fate specification, as well as cell-cycle control. Furthermore, dynamic regulation of cell proliferation occurs in response to multiple external signals. The C. elegans germ line is proving a valuable model for linking genetic, developmental, systemic, and environmental control of cell proliferation. Here, we consider recent studies that contribute to our understanding of germ cell proliferation in C. elegans. We focus primarily on somatic control of germline proliferation, how it differs at different life stages, and how it can be altered in the context of the life cycle and changes in environmental status.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.22268

Authors: Dorota Z. Korta, E. Jane Albert Hubbard

Institutions: NYU Langone Health, New York University

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G2134811482, " TGF-beta and sensory regulation of germline development in C. elegans"., Control of Onset of Meiosis in C. elegans.