Work

Examining interactions between risk factors for psychosis

Year: 2010

Type: article

Abstract: BACKGROUND: For complex multifactorial diseases it seems likely that co-exposure to two risk factors will show a greater than additive relationship on disease risk. AIMS: To test whether greater than additive relationships occur between risk factors for psychosis. METHOD: A cohort study of 50 053 Swedish conscripts. Data on IQ, cannabis use, psychiatric diagnoses, disturbed behaviour and social relations assessed at age 18 were linked to admissions with any non-affective psychoses over a 27-year follow-up period. Statistical interactions between risk factors were examined under both additive and multiplicative models. RESULTS: There was some evidence of interaction for eight of the ten combinations of risk factors under additive models, but for only one combination under multiplicative models. CONCLUSIONS: Multiplicative models describe the joint effect of risk factors more adequately than additive ones do. However, the implications of finding interactions as observed here, or for most interactions reported to date, remain very limited.

Source: The British Journal of Psychiatry

DOI: 10.1192/bjp.bp.109.070904

Authors: Stanley Zammit, Glyn Lewis, Christina Dalman, Peter Allebeck

Institutions: University of Bristol, Cardiff University, Karolinska Institutet

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2059662415