Work

Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function

Year: 2013

Type: article

Abstract: Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion- an emerging subcellular target for its biological actions in tissues.

Source: Redox Biology

DOI: 10.1016/j.redox.2012.11.005

Author: Sruti Shiva

Institution: University of Pittsburgh

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $4,310

Funders: American Heart Association, Hemophilia Center of Western Pennsylvania, National Institutes of Health, National Heart, Lung, and Blood Institute