Work

Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers

Year: 2013

Type: article

Abstract: A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

Source: Advanced Materials

DOI: 10.1002/adma.201203585

Authors: Ruogang Zhao, Thomas Boudou, Wei‐Gang Wang, Christopher S. Chen, Daniel H. Reich

Institutions: Johns Hopkins University, University of Pennsylvania

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences

Awards: G2494578246, Mesenchymal Stem Cells and the Microenvironment, G5080600031, Cadherins, integrins, and mechanochemical signaling, Subcellular Response to Local Forces