P1‐310: Correlations between amyloid and metabolic pet imaging in cognitively normal adults with a family history of late‐onset Alzheimer's disease
Year: 2011
Type: article
Study design: Observational Study
Abstract: Having a parent affected with late-onset Alzheimer's disease (LOAD) is a major risk factor among cognitively normal (NL) individuals. This study examines whether NL with LOAD-parents show preclinical evidence of brain AD, as reflected in increased fibrillar amyloid-beta (Aß) deposition on C-Pittsburgh Compound B (PiB)-PET, a major hallmark of AD pathology, and reduced glucose metabolism on F-fluorodeoxyglucose (FDG)-PET, a proxy for neuronal dysfunction. Forty-five 40-80 year-old NL with 8F-FDG and C-PIB PET examinations were examined, including 15 NL with a maternal history (MH), 15 NL with a paternal history (PH), and 15 NL with negative family history of LOAD (NH). For all cases, the parents’ AD diagnosis was clinician certified. Automated regions-of-interest, statistical parametric mapping, voxel-wise inter-modality correlations and logistic regression were used to examine cerebral-to-cerebellar PiB and FDG standardized uptake value ratios across groups. Groups were comparable for clinical and demographical measures. The MH group showed higher PiB retention and lower metabolism in AD-regions compared to NH and PH, while the PH group showed milder PiB increases and no metabolic reductions compared to NH. Results remained significant controlling for age, gender, education and ApoE. Metabolism and PiB retention were negatively correlated locally in PCC, frontal and parieto-temporal regions in MHPY, whereas no correlations were observed in NH and PH. The combination of Aß deposition and metabolism improved group separation over either measure alone, yielding ≥ 65% accuracy for MH vs NH and PH (P < 0.05).
Source: Alzheimer s & Dementia
Authors: Megan Cummings, Juha Rinne, Lisa Mosconi, Wai Tsui, John Murray, Yi Li, Lidia Glodzik, Pauline McHugh, Schantel Williams, Stanley Goldsmith, Shankar Vallabhajosula, Noora Scheinin, Tapio Viljanen, Kjell Nagren, Mony De Leon
Institutions: New York University, Turku PET Centre, Cornell University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2060209709