Work

Drug development: longer-lived proteins

Year: 2012

Type: review

Abstract: Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biophysical clearance mechanisms, several of which may decrease the drug's circulation time and efficiency. In this tutorial review, we introduce the concepts of physiological protein clearance from the body, and describe several chemical modification and protein engineering approaches used to improve the life span of administered protein therapeutics.

Source: Chemical Society Reviews

DOI: 10.1039/c2cs15289d

Authors: Stephan Kontos, Jeffrey A. Hubbell

Institution: École Polytechnique Fédérale de Lausanne

Language: English

Topic: Protein purification and stability

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2060256808

FWCI: 0.613

Cites: 70

Cited by: 69

Related to: 10