Work

Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems

Year: 2013

Type: article

Abstract: Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts.

Source: Advanced Materials

DOI: 10.1002/adma.201303680

Authors: Daniel D. McKinnon, Dylan W. Domaille, Jennifer N. Cha, Kristi S. Anseth

Institutions: University of Colorado Boulder, Howard Hughes Medical Institute

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, Office of Naval Research, National Institute of General Medical Sciences

Award: Leadership Training in Pharmaceutical Biotechnology