Year: 2006
Type: article
Study design: Observational Study
Abstract: To estimate the relationship between air pollution and lung cancer, a nested case-control study was set up within EPIC (European Prospective Investigation on Cancer and Nutrition). Cases had newly diagnosed lung cancer, accrued after a median follow-up of 7 years among the EPIC ex-smokers (since at least 10 years) and never smokers. Three controls per case were matched. Matching criteria were gender, age (+/-5 years), smoking status, country of recruitment and time elapsed between recruitment and diagnosis. We studied residence in proximity of heavy traffic roads as an indicator of exposure to air pollution. In addition, exposure to air pollutants (NO(2), PM10, SO(2)) was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Cotinine was measured in plasma. We found a nonsignificant association between lung cancer and residence nearby heavy traffic roads (odds ratio = 1.46, 95% confidence interval, CI, 0.89-2.40). Exposure data for single pollutants were available for 197 cases and 556 matched controls. For NO(2) we found an odds ratio of 1.14 (95% CI, 0.78-1.67) for each increment of 10 microg/m(3), and an odds ratio of 1.30 (1.02-1.66) for concentrations greater than 30 microg/m(3). The association with NO(2) did not change after adjustment by cotinine and additional potential confounders, including occupational exposures. No clear association was found with other pollutants.
Source: International Journal of Cancer
DOI: 10.1002/ijc.21801
Authors: Paolo Vineis, Gerard Hoek, Michal Krzyzanowski, Federica Vigna‐Taglianti, Fabrizio Veglia, Luisa Airoldi, Herman Autrup, Alison Dunning, Seymour Garte, Pierre Hainaut, Christian Malaveille, Giuseppe Matullo, Kim Overvad, Ole Raaschou‐Nielsen, Francoise Clavel‐Chapelon, Jacob Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Marco Peluso, Vittorio Krogh, Rosario Tumino, Salvatore Panico, H. Bas Bueno‐De‐Mesquita, Petra H. Peeters, E. Eylin Lund, Carlos A. Gonzalez, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, Lluis Cirera, J. Ramon Quiros, Goran Berglund, Bertil Forsberg, Nicholas E. Day, Tim J. Key, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli
Institutions: Imperial College London, University of Turin, Utrecht University, World Health Organization, Institute for Scientific Interchange, Mario Negri Institute for Pharmacological Research, Aarhus University, University of Cambridge, Centre international de recherche sur le cancer, Aalborg University Hospital, Aarhus University Hospital, Danish Cancer Society, Inserm, Institut Gustave Roussy, German Cancer Research Center, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, National Institute for Public Health and the Environment, University Medical Center Utrecht, UiT The Arctic University of Norway, Institut Català d'Oncologia, Andalusian School of Public Health, Instituto de Salud Pública de Navarra, Gobierno del Principado de Asturias, Lund University, Umeå University, MRC Mitochondrial Biology Unit, Cancer Research UK, University of Oxford
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2060462691