Work

708. Gene Targeting with Triplex-Forming Oligonucletides in the Pyrimidine Motif

Year: 2006

Type: article

Abstract: Triplex-forming oligonucleotides (TFOs) bind DNA in a sequence- specific manner at polypurine/polypyrimidine sites and mediate targeted genome modification. Triplexes are formed by either pyrimidine TFOs, which bind parallel to the purine strand of the duplex (pyrimidine, parallel motif), or purine TFOs, which bind in an anti-parallel orientation (purine, anti-parallel motif). Initial studies demonstrated the ability of TFOs in both motifs to deliver mutagenic agents in a DNA site-specific manner.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.787

Authors: Jennifer M. Kalish, Melissa P. Knauert, Denise C. Hegan, Peter M. Glazer

Institution: Yale University

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

OpenAlex ID: W2060587802

FWCI:

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