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Adenosine: Differential Effect on Blood Flow to Subregions of the Upper Gastrointestinal Tract

Year: 1994

Type: article

Abstract: The potential of adenosine to regulate organ blood flow (ml/min/100 g tissue) in the intact rabbit upper alimentary tract was evaluated using the radioactive microsphere technique. Adenosine (1.0 mumole/kg/min) produced significant, greater than threefold increases in esophageal mucosal blood flow (37 +/- 2 to 127 +/- 47) and threefold increases in antral mucosal (39 +/- 3 to 144 +/- 24) and transmural small intestinal blood flow (duodenum, 60 +/- 13 to 187 +/- 22; jejunum, 42 +/- 3 to 138 +/- 16; ileum, 27 +/- 2 to 80 +/- 22). Inosine did not reproduce these effects. P1-purinergic receptor antagonism with theophylline blocked the effects of adenosine. 5'-(N-Ethylcarboxamido)adenosine, an agonist of A2-subtype, P1-purinergic receptors, increased gastrointestinal organ blood flow similarly to adenosine with nmole/kg/min doses. Similar doses of the A1-subtype agonist, N5-cyclohexyladenosine, were ineffective, but mumole/kg/min doses produced small effects on esophageal mucosa and ileum. Our results indicate that in rabbit alimentary organs, adenosine preferentially increases blood flow to esophageal mucosa, antral mucosa, and small intestine. Its effects are mediated by the A2-subtype of P1-purinergic receptors.

Source: Journal of Surgical Research

DOI: 10.1006/jsre.1994.1073

Authors: Marie F. Pennanen, Barbara L. Bass, Adam J. Dziki, John W. Harmon

Institutions: Georgetown University, George Washington University

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,590