Work

Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine‐induced excitation of mammalian motor nerve endings

Year: 1989

Type: article

Abstract: Pertussis toxin (PTX), which blocks certain classes of guanine nucleotide binding proteins (G proteins), consistently blocked the inhibitory effects of adenosine (100 microM-250 microM) on quantal acetylcholine (ACh) secretion in rat phrenic nerve hemidiaphragm preparations. PTX pretreatment also highlighted long-lasting increases in evoked ACh release elicited by adenosine. The results suggest that specific G proteins are involved in mediating the inhibitory effects of adenosine at motor nerve endings.

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.1989.tb11918.x

Authors: E.M. Silinsky, C. Solsona, J.K. Hirsh

Institutions: Northwestern University, Universitat de Barcelona

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Ministerio de Economía y Competitividad, U.S. Public Health Service, National Institute of Neurological Disorders and Stroke