Year: 2014
Type: article
Abstract: Stefan Borsley opened the discussion of the paper by Hedi Mattoussi : Are there any advantages to using this polymeric His binding system over traditional thiol-bound ligands?Hedi Mattoussi responded: The use of a multi-coordinating polymer ligand having several histidine groups for surface coordination may be benecial for gold nanorods (AuNRs).These NRs tend to have large surface areas, and a polymer structure provides stronger binding and better interactions with the hydrophilic surrounding medium.Multi-thiol polymer coating would also provide stronger affinity, nonetheless.I should also stress the importance of using a PEGrich polymer for these systems.Dalibor Soukup asked: In your presentation you have shown that your particles are very stable in media.However, I was wondering if it is pure medium without serum or a complete medium with serum, as serum proteins can spontaneously adsorb on the surface of highly charged nanoparticles?This would increase the hydrodynamic size of particles and in turn affect the stability of nanoparticles.Typically, in order to avoid this, PEG-functionalized nanoparticles have been introduced, however, are there any other chemical coatings known that could do the same?Hedi Mattoussi answered: The polymer-coated nanoparticles we discussed are stable in complete growth media.I should add that protein corona formation, which stems from adsorbed serum proteins on the nanoparticles (oen discussed these days), takes place with electrostatically-stabilized nanoparticles, such as the very commonly used citrate-stabilized gold nanoparticles (AuNPs).One of the most effective routes to reducing those problems is to use PEG or zwitterion coating.Such coating circumvents reliance on charge stabilization and eliminates protein adsorption on the nanoparticles.
Source: Faraday Discussions
DOI: 10.1039/c4fd90079k
Authors: Peter Dobson, Lanry L. Yung, Liane Rossi, Zoe Pikramenou, Sara Carreira, Paresh Ray, Catherine Amiens, Katherine Brown, Maha Abdollah, Dejian Zhou, Mauro Prato, Sandhya Moise, Lucio Litti, Matthew Todd, Kristian Göeken, Stefan Borsley, Amelie Heuer-Jungemann, Oliver Reiser, Peter Harvey, Thomas Carter, Maya Thanou, Dalibor Soukup, Anna Lesniak, Hedi Mattoussi, Siti Fatimah Abdul Ghani
Institution: University College Dublin
Language: English
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2060948043