Work

A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism

Year: 2013

Type: article

Abstract: Mitochondrial metabolism influences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S-adenosylmethionine.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-13-0059

Authors: Barbara Martinez-Pastor, Claudia Cosentino, Raul Mostoslavsky

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green