Work

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

Year: 1994

Type: review

Abstract: Experiments with transgenic mice expressing genes encoding both antigens in defined tissues and T-cell receptor genes of known specificities have enhanced our understanding of the mechanisms involved in the pathogenesis of autoimmune states. They have also shed light on the means by which potentially autoreactive cells may be prevented from exerting their autoaggressive potential. The value of the transgenic approach is that it can overcome the low frequency of peptide-specific T cells occurring in normal animals, and also provide a tissue-specific, cognate antigen that is absent in controls. These factors allow reactive T cells to be isolated or quantified by flow cytometry and their responses to antigen in vitro and in vivo be defined.

Source: Current Opinion in Immunology

DOI: 10.1016/0952-7915(94)90010-8

Authors: Jacques F.A.P. Miller, Richard A. Flavell

Institutions: The Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, Howard Hughes Medical Institute, Yale University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,410