Work

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

Year: 2005

Type: article

Abstract: Hepatic peptide hormone hepcidin is the key regulator of iron metabolism and the mediator of anemia of inflammation. Previous studies indicated that interleukin-6 (IL-6) mediates hepcidin increase and consequent hypoferremia during inflammation. Here we used an in vivo human endotoxemia model to analyze the effects of lipopolysaccharide (LPS) as a more upstream inflammation activator. The temporal associations between plasma cytokines, hepcidin levels, and serum iron parameters were studied in 10 healthy individuals after LPS injection. IL-6 was dramatically induced within 3 hours after injection, and urinary hepcidin peaked within 6 hours, followed by a significant decrease in serum iron. Serum prohepcidin showed no significant change within a 22-hour time frame. These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system.

Source: Blood

DOI: 10.1182/blood-2005-03-1159

Authors: Erwin Kemna, Peter Pickkers, Elizabeta Nemeth, Hans van der Hoeven, Dorine Swinkels

Institutions: Radboud University Nijmegen, University of California, Los Angeles, Radboud University Medical Center

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2061035099