Work

Questioning Regulation of Two-Pore Channels by NAADP

Year: 2013

Type: article

Abstract: -selective channels apparently insensitive to NAADP [9;10]. Given the two fundamental characteristics defining an ion channel comprise the opening stimulus and the nature of the permeant ions, scrutiny of these seeming irreconcilable viewpoints is essential. The purpose of this commentary is to distil the remaining consensus while interrogating these divergent viewpoints. From this analysis, critical experimental needs are identified.

Source: Messenger

DOI: 10.1166/msr.2013.1027

Authors: Jonathan S. Marchant, Sandip Patel

Institutions: University of Minnesota, University College London

Language: English

Topic: Calcium signaling and nucleotide metabolism

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, Biotechnology and Biological Sciences Research Council, National Institute of General Medical Sciences

Awards: The molecular basis for calcium release by NAADP, A role for a novel animal endo-lysosomal Ca2+/H+ exchanger in Ca2+ signalling and chemotaxis., Functional architecture of intracellular Ca2+ signals