Year: 2009
Type: article
Abstract: Two chapters in this volume deal with Immunology of Infectious Diseases.Circulating monocytes are increasingly implicated as essential players in defense against a range of microbial pathogens by supplying tissues with macrophage and dendritic cells precursors.In humans and mice, monocytes either specifically traffic into inflamed tissues or, in the absence of overt inflammation, constitutively maintain tissue macrophage/ dendritic cells populations.Inflammatory monocytes respond rapidly to microbial stimuli by secreting cytokines and antimicrobial factors, express the CCR2 chemokine receptor, and traffic to sites of microbial infection in response to monocyte chemoattractant protein (MCP)-1 (CCL2) secretion.In a very interesting issue, the in vivo mechanisms that promote chemokine secretion, monocyte differentiation and trafficking, and finally monocyte-mediated microbial killing remain active are focused by N.V. SERBINA et al.
Authors: William E. Paul, Dan R. Littman
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2061131612