Work

Sociodemographic Predictors of Survival in Differentiated Thyroid Cancer: Results from the SEER Database

Year: 2012

Type: article

Abstract: Background. Differentiated thyroid carcinoma (DTC) is prognosticated upon a combination of tumor characteristics, such as histology and stage, and patient age. DTC is also notable for having a strong female predominance. Using a nationwide database with long follow-up times, we explored the interplay between tumor biology and patient characteristics in predicting mortality. Methods. The Surveillance, Epidemiology, and End Results (SEER) registry data 1973-2005 was examined for patients with DTC as their only known malignancy. Cox multivariate analyses were used to generate mortality hazard ratios to evaluate the effects of age, gender, ethnicity, and marital status. Results. We identified 55,995 patients with DTC as their only malignancy. Consistent with the existing literature, the tumors are primarily diagnosed in women (77.5%), and predominantly affect Caucasians (78.3%). Female gender had a protective effect resulting in a 37% decrease in mortality. Age at diagnosis predicted mortality over age 40. Black ethnicity was associated with a 51% increase in mortality compared to Caucasians. Conclusion. Multiple demographic factors predict mortality in patients with DTC after adjusting for tumor characteristics, and they appear to have complex interactions. Recognizing the importance of these factors may enable clinicians to better tailor therapy.

Source: ISRN Endocrinology

DOI: 10.5402/2012/384707

Authors: Lily E. Johnston, Hop S. Tran Cao, David C. Chang, Michael Bouvet

Institutions: University of California San Diego, Moores Cancer Center

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: diamond

Funder: National Cancer Institute