Work

Fluid flow and guidance of collective cell migration

Year: 2010

Type: article

Abstract: Collective cell migration is emerging as a significant component of many biological processes including metazoan development, tissue maintenance and repair and tumor progression. Different contexts dictate different mechanisms by which migration is guided and maintained. In vascular endothelia subjected to significant shear stress, fluid flow is utilized to properly orient a migrating group of cells. Recently, we discovered that the developing zebrafish pronephric epithelium undergoes a similar response to luminal fluid flow, which guides pronephric epithelial migration towards the glomerulus. Intratubular migration leads to significant changes in kidney morphology. This novel process provides a powerful in vivo model for further exploration of the mechanisms underlying mechanotransduction and collective migration.

Source: Cell Adhesion & Migration

DOI: 10.4161/cam.4.3.11428

Authors: Aleksandr Vasilyev, Iain A. Drummond

Institution: Massachusetts General Hospital

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,306

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases