Work

MicroRNA 125a and its regulation of the p53 tumor suppressor gene

Year: 2009

Type: article

Abstract: MicroRNA (miRNA) are a class of non-coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA-125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA-125 (miRNA-125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR-125a and the 3'-UTR of p53. Our findings add miRNA-125a to the growing list of miRNA with oncogenic targets.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2009.10.002

Authors: Yingjie Zhang, Jin-Song Gao, Xiaoli Tang, Lynne D. Tucker, Peter Quesenberry, Isidore Rigoutsos, Bharat Ramratnam

Institutions: Brown University, IBM Research - Thomas J. Watson Research Center

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Research Resources

Awards: COBRE Center for Cancer Research Development, Stem Cell Biology: New Directions in Clinical and Basic Research, COBRE Center for Cancer Research Development, Providence/Boston Center for AIDS Research (CFAR), HIV and Other Infectious Consequences of Substance Use

OpenAlex ID: W2061666056

FWCI: 4.251

Cites: 23

Cited by: 97

Related to: 10