Work

Shock block for improved immunotherapy

Year: 2012

Type: article

Abstract: Cancer cells use heat shock proteins (HSP) to stabilize growth/survival-associated client proteins such as receptor tyrosine kinases (RTKs), in vivo. Our recent work suggests that chemical HSP90 inhibitors combined with a vaccination strategy targeting HSP90 client proteins that are (over)expressed in the tumor microenvironment yields superior therapeutic benefit.

Source: OncoImmunology

DOI: 10.4161/onci.21174

Authors: Aparna Rao, Devin B. Lowe, Walter J. Storkus

Institution: University of Pittsburgh

Language: English

Topic: Heat shock proteins research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913