Work

Binding of N -Substituted Erythromycylamines to Ribosomes

Year: 1976

Type: article

Abstract: Several N-substituted erythromycylamines were evaluated for their ability to inhibit the binding of [(14)C]erythromycin to ribosomes. The association and dissociation constants for the binding of each compound to Escherichia coli ribosomes were determined. These studies have resulted in the development of three types of probes for topological studies of the erythromycin-binding site and the ribosome: the chemically reactive bromoacetamido, the photoreactive N-(2)-nitro-4-azidophenyl)glycinamido, and the fluorescent fluorescein isothiocyanate derivatives of 9(S)-erythromycylamine.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.9.1.131

Authors: Robert Vince, David Weiss, Sidney Pestka

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

OpenAlex ID: W2062038195

FWCI: 1.495

Cites: 14

Cited by: 24

Related to: 10