Work

Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger

Year: 2012

Type: article

Abstract: The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release.

Source: Organic Letters

DOI: 10.1021/ol301490h

Authors: Mohannad Abdo, Stephen P. Brown, Joel R. Courter, Matthew J. Tucker, Robin M. Hochstrasser, Amos B. Smith

Institution: University of Pennsylvania

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources

Awards: G1069440171, G255748793, ULTRAFAST OPTICAL PROCESSES LABORATORY