Loss of NF-κB Control and Repression of Prdx6 Gene Transcription by Reactive Oxygen Species-driven SMAD3-mediated Transforming Growth Factor β Signaling
Year: 2009
Type: article
Abstract: Activation of transforming growth factor β (TGFβ) in response to increased reactive oxygen species (ROS) leads to pathophysiology of cells/tissues by overmodulation of gene transcription. PRDX6 plays a rheostat role in regulating gene transcription by controlling cellular ROS in maintaining homeostasis; thus, fine tuning of Prdx6 expression is required to optimize ROS levels. Using Prdx6- and Smad3-depleted cells, we show that Prdx6−/− cells bear active NF-κB and Smad3, and repression of Prdx6 transcription in redox-active cells (Prdx6−/−) is due to ROS-induced dominant Smad3-mediated TGFβ signaling.
Source: Journal of Biological Chemistry
Authors: Nigar Fatma, Eri Kubo, Yoshihiro Takamura, Keiichi Ishihara, Claudia Garcia, David C. Beebe, Dhirendra P. Singh
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2062250649