Work

The Effect of Gold Nanorods on Cell-Mediated Collagen Remodeling

Year: 2008

Type: article

Abstract: Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding beta-actin, alpha-smooth muscle actin, and collagen type I. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.

Source: Nano Letters

DOI: 10.1021/nl802142h

Authors: Patrick N. Sisco, Christopher G. Wilson, Ekaterina Mironova, Sarah C. Baxter, Catherine J. Murphy, Edie C. Goldsmith

Institution: University of South Carolina

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute