Work

Human Papillomavirus Type 16 (HPV16) E6/E7-Specific Cytotoxic T Lymphocytes (CTLs) for Immunotherapy of HPV-Associated Malignancies

Year: 2012

Type: article

Abstract: Vaccines prevent HPV-associated cancer (Ca), but their use as therapy for established Ca has been disappointing. Although the target tumor cells express the viral E6 and E7 antigens (Ag), patients' immune responses against virally infected cells are limited, even after active immunization, likely due to negative environmental cues that block initial tumor cell recognition and subsequent T cell (TC) activation and expansion in vivo. We postulated that ex vivo stimulation of patient TCs in an immunologically favorable milieu would allow us to reactivate tumor-directed CTLs.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.049