Work

A Peptide Antagonist of the TLR4–MD2 Interaction

Year: 2009

Type: article

Abstract: Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling.

Source: ChemBioChem

DOI: 10.1002/cbic.200800769

Authors: Peter F. Slivka, Mitesh Shridhar, Gui‐in Lee, Deanne W. Sammond, Mark R. Hutchinson, Alexander J. Martinko, Madison M. Buchanan, Page W. Sholar, Jeffrey J. Kearney, Jacqueline A. Harrison, Linda R. Watkins, Hang Yin

Institutions: University of Colorado Boulder, Pennsylvania State University, University of Colorado System

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Colorado Boulder, National Institute on Drug Abuse, National Institute of General Medical Sciences, National Institute of Dental and Craniofacial Research

Awards: G1511558453, G1927391410, G3342743863, Interdisciplinary Predoctoral Training in Molecular Biophysics, Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation, Pain facilitation via neuron-to-glia signaling, Immune and Gilia Regulation of Pain & Analgesic Actions

OpenAlex ID: W2062487226

FWCI: 1.726

Cites: 27

Cited by: 50

Related to: 10