Phosphoramidites: Marvellous Ligands in Catalytic Asymmetric Conjugate Addition
Year: 2000
Type: review
Abstract: The development of an efficient catalytic system for enantioselective carbon-carbon bond formation by 1,4-addition of organometallic reagents (organolithium, Grignard, and organozinc reagents) to enones is a major challenge in organic synthesis. This Account presents the breakthrough realized in this field using chiral phosphoramidite ligands for copper-catalyzed dialkylzinc additions. Applications in catalytic routes to cycloalkanones as well as tandem and annulation procedures with excellent enantioselectivities are discussed.
Source: Accounts of Chemical Research
DOI: 10.1021/ar990084k
Author: Ben L. Feringa
Institution: University of Groningen
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2062487750