Work

C-factor: A cell-cell signaling protein required for fruiting body morphogenesis of M. Xanthus

Year: 1990

Type: article

Abstract: During fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. From nascent wild-type fruiting bodies we have purified a polypeptide of 17 kd called C-factor, which, at approximately 1 to 2 nM, restores normal development to csgA mutant cells. C-factor activity is not recovered from extracts of unstarved, growing cells or csgA mutant cells. The amino acid sequence from purified C-factor demonstrates that it is the product of the csgA gene. C-factor is active over a narrow range of concentration and has properties of a morphogenetic paracrine signal.

Source: Cell

DOI: 10.1016/0092-8674(90)90211-v

Authors: Seung K. Kim, Dale Kaiser

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $11,400

Funders: U.S. Department of Energy, National Institute of General Medical Sciences