Iron oxide nanorods as high-performance magnetic resonance imaging contrast agents
Year: 2015
Type: article
Abstract: An efficient magnetic resonance imaging (MRI) contrast agent with a high R2 relaxivity value is achieved by controlling the shape of iron oxide to rod like morphology with a length of 30-70 nm and diameter of 4-12 nm. Fe3O4 nanorods of 70 nm length, encapsulated with polyethyleneimine show a very high R2 relaxivity value of 608 mM(-1) s(-1). The enhanced MRI contrast of nanorods is attributed to their higher surface area and anisotropic morphology. The higher surface area induces a stronger magnetic field perturbation over a larger volume more effectively for the outer sphere protons. The shape anisotropy contribution is understood by calculating the local magnetic field of nanorods and spherical nanoparticles under an applied magnetic field (3 Tesla). As compared to spherical geometry, the induced magnetic field of a rod is stronger and hence the stronger magnetic field over a large volume leads to a higher R2 relaxivity of nanorods.
Source: Nanoscale
DOI: 10.1039/c5nr00055f
Institution: Indian Institute of Technology Bombay
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Funders: Northwestern University, Department of Science and Technology, Ministry of Science and Technology, India, Council of Scientific and Industrial Research, India, Department of Electronics and Information Technology, Ministry of Communications and Information Technology, Indian Institute of Technology Bombay, Industrial Research and Consultancy Centre
OpenAlex ID: W2062647630