Work

Understanding decision-making deficits in neurological conditions: insights from models of natural action selection

Year: 2007

Type: article

Abstract: Models of natural action selection implicate fronto-striatal circuits in both motor and cognitive 'actions'. Dysfunction of these circuits leads to decision-making deficits in various populations. We review how computational models provide insights into the mechanistic basis for these deficits in Parkinson's patients and those with ventromedial frontal damage. We then consider implications of the models for understanding behaviour and cognition in attention-deficit/hyperactivity disorder (ADHD). Incorporation of cortical noradrenaline function into the model improves action selection in noisy environments and accounts for response variability in ADHD. We close with more general clinical implications.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2007.2058

Authors: Michael J Frank, Anouk Scheres, Scott J Sherman

Institution: University of Arizona

Language: English

Topic: Neural and Behavioral Psychology Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2062652125

FWCI: 5.427

Cites: 152

Cited by: 170

Related to: 9