Work

Two-state models of protein folding kinetics

Year: 1997

Type: article

Abstract: The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic model is justified if protein molecules rapidly equilibrate between different unfolded conformations prior to complete folding. Here I show that this rapid equilibration is a natural consequence of reasonable assumptions about reaction rate constants and folding thermodynamics.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.94.1.148

Author: Robert Zwanzig

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2062784336

FWCI: 1.885

Cites: 7

Cited by: 166

Related to: 10