Work

Highly Enantioselective Catalytic Conjugate Addition and Tandem Conjugate Addition–Aldol Reactions of Organozinc Reagents

Year: 1997

Type: article

Abstract: Complete stereocontrol with the added advantage of functional-group tolerance in copper-catalyzed 1,4-additions of organozinc reagents to enones has been achieved for the first time with the chiral phosphoramidite L* as ligand in the copper complex [Eq. (a), Tf = trifluoromethanesulfonate]. The zinc enolate intermediate of the reaction can be trapped with aldehydes.

Source: Angewandte Chemie International Edition in English

DOI: 10.1002/anie.199726201

Authors: Ben L. Feringa, Mauro Pineschi, Leggy A. Arnold, Rosalinde Imbos, André H. M. de Vries

Institution: University of Groningen

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2062799381

FWCI: 17.68

Cites: 30

Cited by: 453

Related to: 10