Work

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

Year: 2010

Type: article

Abstract: The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c0ob00579g

Authors: P. Matthew Joyner, Jinman Liu, Zhijun Zhang, Justin Merritt, Fengxia Qi, Robert H. Cichewicz

Institutions: University of Oklahoma, University of Oklahoma Health Sciences Center

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green