Work

Reduced Intensity Conditioning with Pentostatin and Low-Dose TBI in Patients with Relapsed Hematologic Malignancies

Year: 2012

Type: article

Abstract: Reduced intensity conditioning regimens have been developed which have resulted in successful engraftment of allogeneic stem cells with reduced regimen-related toxicities. We previously demonstrated in a Phase II study that a regimen of extracorporeal photopheresis (ECP), pentostatin (4mg/m2 CIVI days -5 and -4) and 600 cGy of TBI was associated with stable engraftment, a NRM of 11% and a reduced incidence of acute and chronic GVHD. We now report results from 37 pts with lymphoid malignancies treated with pentostatin and TBI 600cGy (days -3 and -2) followed by allogeneic stem cell infusion.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.356