Year: 1998
Type: review
Abstract: Lactacystin, a microbial natural product that inhibits cell proliferation and induces neurite outgrowth in a murine neuroblastoma cell line, has become a widely used reagent in functional studies of the proteasome, a high molecular weight, multicatalytic protease complex responsible for most non-lysosomal intracellular protein degradation. The proteasome is composed of a 20 S catalytic core and additional subunits that are thought to be involved in the recognition and unfolding of ubiquitinated proteins; the composite structure has a sedimentation coefficient of 26 S.
Source: Journal of Biological Chemistry
Authors: Gabriel Fenteany, Stuart L. Schreiber
Institutions: Howard Hughes Medical Institute, Harvard University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2062886087