Work

CD14+S100A9+ Myeloid-derived Suppressor Cells Portend Decreased Survival in Patients with Advanced Lung Cancer

Year: 2012

Type: editorial

Abstract: secretion?Would transgenic correction of the HPS-2 epithelial defect in HPS1/2 double-mutant mice prevent the development of spontaneous pulmonary fibrosis?Is epithelial-specific correction of the underlying genetic defect or inhibition of AECII apoptosis a potential therapy for HPS pulmonary fibrosis?Further research is indicated to answer these questions and improve the understanding of HPS pulmonary fibrosis and fibrotic lung disease in general.

Source: American Journal of Respiratory and Critical Care Medicine

DOI: 10.1164/rccm.201209-1597ed

Authors: Sherven Sharma, Steven Dubinett, Ravi Salgia

Institutions: University of California, Los Angeles, VA Greater Los Angeles Healthcare System, UCLA Jonsson Comprehensive Cancer Center, University of Chicago

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Center for Advancing Translational Sciences