Work

Replication of avian influenza viruses in equine tracheal epithelium but not in horses

Year: 2013

Type: article

Abstract: We evaluated a hypothesis that horses are susceptible to avian influenza viruses by in vitro testing, using explanted equine tracheal epithelial cultures, and in vivo testing by aerosol inoculation of ponies. Results showed that several subtypes of avian influenza viruses detectably replicated in vitro. Three viruses with high in vitro replication competence were administered to ponies. None of the three demonstrably replicated or caused disease signs in ponies. While these results do not exhaustively test our hypothesis, they do highlight that the tracheal explant culture system is a poor predictor of in vivo infectivity.

Source: Influenza and Other Respiratory Viruses

DOI: 10.1111/irv.12188

Authors: Thomas M. Chambers, Udeni B. R. Balasuriya, Stephanie E. Reedy, Ashish Tiwari

Institution: University of Kentucky

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Vanderbilt University, St. Jude Children's Research Hospital, Kentucky Science and Engineering Foundation