Plasma Phospholipid Long-Chain n-3 Polyunsaturated Fatty Acids and Body Weight Change
Year: 2011
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.
Source: Obesity Facts
DOI: 10.1159/000330710
Authors: Marianne U. Jakobsen, Claus Dethlefsen, Karen M. Due, Nadia Slimani, Veronique Chajès, Anne M. May, Thorkild I.A. Sørensen, Jytte Halkjær, Anne Tjønneland, Francoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Antonia Trichopoulou, Dimosthenis Zylis, George Makrygiannis, Domenico Palli, Amalia Mattiello, Giovanna Tagliabue, Daphne L. van der A, H.B. Bueno-de-Mesquita, Laudina Rodríguez, Noémie Travier, Esther Molina-Montes, José M. Huerta, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Ingegerd Johansson, Göran Hallmans, Kay-Tee Khaw, Nicholas J. Wareham, Francesca Crowe, Isabelle Romieu, Elio Riboli, Petra H.M. Peeters, Kim Overvad
Institutions: Aarhus University, Aarhus University Hospital, Aalborg University, Centre international de recherche sur le cancer, Utrecht University, University of Copenhagen, Danish Cancer Society, Université Paris-Sud, Institut Gustave Roussy, German Cancer Research Center, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Hellenic Health Foundation, Istituto per lo Studio e la Prevenzione Oncologica, University of Naples Federico II, Fondazione IRCCS Istituto Nazionale dei Tumori, National Institute for Public Health and the Environment, Institut d'Investigació Biomédica de Bellvitge, Andalusian School of Public Health, Centro de Investigación Biomédica en Red, Lund University, Umeå University, University of Cambridge, Addenbrooke's Hospital, University of Oxford, Imperial College London
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2063462248