Work

Nanopore-Based Fourth-Generation DNA Sequencing Technology

Year: 2015

Type: review

Abstract: Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications.

Source: Genomics Proteomics & Bioinformatics

DOI: 10.1016/j.gpb.2015.01.009

Authors: Yanxiao Feng, Yuechuan Zhang, Cuifeng Ying, Deqiang Wang, Chunlei Du

Institutions: Chinese Academy of Sciences, Chongqing Institute of Green and Intelligent Technology, University of Chinese Academy of Sciences, University of Electronic Science and Technology of China, Nankai University

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,850

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, China Postdoctoral Science Foundation, West Light Foundation of the Chinese Academy of Sciences