Work

Mechanotransduction and the regulation of protein synthesis in skeletal muscle

Year: 2004

Type: article

Abstract: Repeated bouts of resistance exercise produce an increase in skeletal muscle mass. The accumulation of protein associated with the growth process results from a net increase in protein synthesis relative to breakdown. While the effect of resistance exercise on muscle mass has long been recognized, the mechanisms underlying the link between high-resistance contractions and the regulation of protein synthesis and breakdown are, to date, poorly understood. In the present paper skeletal muscle will be viewed as a mechanosensitive cell type and the possible mechanisms through which mechanically-induced signalling events lead to changes in rates of protein synthesis will be examined.

Source: Proceedings of The Nutrition Society

DOI: 10.1079/pns2004357

Authors: T. A. Hornberger, K. A. Esser

Institution: University of Illinois Chicago

Language: English

Topic: Muscle metabolism and nutrition

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

Open Access status: bronze

Funders: National Aeronautics and Space Administration, Pfizer, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Award: Intracellular signaling during skeletal muscle hypertrophy