Work

Higher Baseline CD4 Cell Count Predicts Treatment Interruptions and Persistent Viremia in Patients Initiating ARVs in Rural Uganda

Year: 2012

Type: article

Study design: Observational Study

Abstract: We examined the association between CD4 cell count and adherence in a cohort of Ugandans initiating antiretrovirals (ARVs). Outcomes were (a) adherence <90%; (b) any treatment interruptions > 72 hours; (c) number of treatment interruptions; and (d) HIV-RNA >400 copies/mL. We fit regression models to estimate associations with our exposure of interest, baseline CD4 cell count ≥ 250 cells/μL (n = 60) vs <250 cells/μL (n = 413). CD4 cell count ≥250 cells/μL was independently associated with increased odds and number of treatment interruptions and increased odds of persistent viremia. Interventions to support adherence in patients with higher CD4 cell counts should be considered as drug availability to this population increases.

Source: JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI: 10.1097/qai.0b013e3182800daf

Authors: Susan A. Adakun, Mark J. Siedner, Conrad Muzoora, Jessica E. Haberer, Alexander C. Tsai, Peter W. Hunt, Jeff N. Martin, David R. Bangsberg

Institutions: Mbarara University of Science and Technology, Massachusetts General Hospital, University of California, San Francisco, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Johns Hopkins University, Mbarara University of Science and Technology, National Institutes of Health, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center

Awards: G1184869378, G200995756, G209787586, G2586943461, G285982522, G446944062, Microenterprise to empower and improve health of HIV+ women in Uganda, Mentoring Patient Oriented Adherence Research in Uganda, G688529966, Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMC, Program for AIDS Clinical Research Training (PACRT), G966175068, G97119092

OpenAlex ID: W2063578992

FWCI: 3.437

Cites: 27

Cited by: 45

Related to: 10